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Literature summary extracted from

  • Fan, Y.; Huang, J.; Kieran, N.; Zhu, M.Y.
    Effects of transcription factors Phox2 on expression of norepinephrine transporter and dopamine beta-hydroxylase in SK-N-BE(2)C cells (2009), J. Neurochem., 110, 1502-1513.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Homo sapiens
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.1 SK-N-BE(2)C cell neuroblastoma cell line Homo sapiens
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Synonyms

EC Number Synonyms Comment Organism
1.14.17.1 DBH
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 Homo sapiens
1.14.17.1 dopamine beta-hydroxylase
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 Homo sapiens

Expression

EC Number Organism Comment Expression
1.14.17.1 Homo sapiens transfection of shRNAs specific to Phox2a or Phox2b genes significantly reduces mRNA and protein levels of DBH after shutdown of endogenous Phox2, which is accompanied by a decreased [(3)H]norepinephrine uptake. Reduced DBH expression caused by the shRNA specific to Phox2a can be reversed by transfection with Phox2b cDNA and vice versa. Cotransfection with both shRNAs specific to Phox2a and Phox2b genes does not further reduce mRNA and protein levels of DBH down
1.14.17.1 Homo sapiens transfection of 0.1 to 5 microg of cDNAs of Phox2a or Phox2b significantly increases mRNA and protein levels of DBH (up to 47%) in a concentration-dependent manner. Simultanoeus transfection with both Phox2a and Phox2b does not further increase mRNA and protein levels of DBH up

General Information

EC Number General Information Comment Organism
1.14.17.1 physiological function determinant role of Phox2a and Phox2b on the expression and function of DBH in vitro Homo sapiens